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Literature summary for 2.4.1.228 extracted from

  • Jacob, F.; Alam, S.; Konantz, M.; Liang, C.Y.; Kohler, R.S.; Everest-Dass, A.V.; Huang, Y.L.; Rimmer, N.; Fedier, A.; Schoetzau, A.; Lopez, M.N.; Packer, N.H.; Lengerke, C.; Heinzelmann-Schwarz, V.
    Transition of mesenchymal and epithelial cancer cells depends on alpha1-4 galactosyltransferase-mediated glycosphingolipids (2018), Cancer Res., 78, 2952-2965 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
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 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NPC4
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-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell globo series-related genes, and in particular, A4GALT, are elevated in epithelial cancer cells and associated with improved patient's outcome Homo sapiens
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Synonyms

Synonyms Comment Organism
A4GalT
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens globo series-related genes, and in particular, A4GALT, are elevated in epithelial cancer cells and associated with improved patient's outcome up

General Information

General Information Comment Organism
malfunction deletion of A4GALT significantly increases the number of extravasated cells and more clusters are formed as compared with parental cells. The deletion of A4GALT leads to increased cell motility and invasiveness in vitro as well as in vivo, features commonly accompanied with epithelial-to-mesenchymal transition Homo sapiens
physiological function the A4GALT gene encodes the alpha1-4 galactosyltransferase, a key enzyme responsible for synthesis of globoside glycosphingolipids. Globo series-related genes, and in particular, A4GALT, are elevated in epithelial cancer cells and associated with improved patient's outcome Homo sapiens