Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | tumour stress activation of glucosylceramide synthase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol | i.e. PPMP, a glycosphingolipid synthesis inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H-1299 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GCS | - |
Homo sapiens |
glucosylceramide synthase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | effect of GCS inhibitor DL-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol and multidrug resistance 1/P-glycoprotein, MDR1, pump inhibitor cyclosporin A on expression and cisplatin cytotoxicity. Enzyme inhibition potentiates cisplatin cytotoxicity in H1299 cells and abolishes cell surface globotriaosylceramide (Gb3) expression of resistant cells | Homo sapiens |
physiological function | Ceramide increases in response to chemotherapy, leading to proliferation arrest and apoptosis. A tumour stress activation of glucosylceramide synthase follows to eliminate ceramide by formation of glycosphingolipids (GSLs) such as globotriaosylceramide (Gb3), the functional receptor of verotoxin-1 | Homo sapiens |