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Literature summary for 2.4.1.228 extracted from
- A novel, promoter-based, target-specific assay identifies 2-deoxy-D-glucose as an inhibitor of globotriaosylceramide biosynthesis (2009), FEBS J., 276, 5191-5202.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-galactose + lactosylceramide | Homo sapiens | - |
UDP + globotriaosylceramide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | - |
Homo sapiens | - |
| HML-Gb3 cell | - |
Homo sapiens | - |
| HUVEC cell | - |
Homo sapiens | - |
| NCCIT cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-galactose + lactosylceramide | - |
Homo sapiens | UDP + globotriaosylceramide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha1,4-galactosyltransferase | - |
Homo sapiens |
| GB3 synthase | - |
Homo sapiens |
| Gb3S | - |
Homo sapiens |
| globotriaosylceramide synthase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | 10 mM 2-deoxy-D-glucose markedly reduces endogenous globotriaosylceramide synthase mRNA levels, can control globotriaosylceramide biosynthesis through the inhibition of globotriaosylceramide synthase transcription | down |
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Release 2023.1 (January 2023)
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