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Literature summary for 2.4.1.228 extracted from

  • Schweppe, C.H.; Bielaszewska, M.; Pohlentz, G.; Friedrich, A.W.; Buentemeyer, H.; Alexander Schmidt, M.; Kim, K.S.; Peter-Katalini?, J.; Karch, H.; Muething, J.
    Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity (2008), Glycoconj. J., 25, 291-304.
    View publication on PubMed
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Application

Application Comment Organism
medicine infections caused by Shiga toxin-producing Escherichia coli result in diarrhea, bloody diarrhea, and the hemolytic uremic syndrom, thus, it is important to better understand the pathways of intracellular transport of the toxin and to develop preventive and therapeutic measures for Shiga toxin-mediated diseases Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide Homo sapiens
-
 UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NPC4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
EAhy 926 cell
-
 Homo sapiens
-
endothelial cell
-
 Homo sapiens
-
human brain microvascular endothelial cell
-
 Homo sapiens
-
HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide
-
 Homo sapiens UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide
-
 ?

Synonyms

Synonyms Comment Organism
alpha1,4-galactosyltransferase
-
 Homo sapiens
Gb3Cer synthase
-
 Homo sapiens