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Literature summary for 2.4.1.228 extracted from
- alpha-1,4Galactosyltransferase activity and Gbeta3Cer expression in human leukemia/lymphoma cell lines (1995), Glycoconj. J., 12, 680-689.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0013 | - |
lactosylceramide | - |
Homo sapiens |  |
| 0.52 | - |
UDP-galactose | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | THP-1 cells | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosylceramide | Homo sapiens | - |
UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosylceramide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
leukaemia-myeloid cell lines: K562, KG-1, HL-60, and THP-1, lymphoma-lymphoid cell lines: Reh, Daudi, Raji, RPMI 8226, CCRF-CEM, and MOLT-4 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| DAUDI cell | - |
Homo sapiens | - |
| additional information | THP-1, RPMI 8226, Daudi, and Raji cell lines with detectable enzyme activity, no detectable enzyme activity: K562, KG-1, HL-60, Reh, MOLT-4, CCRF-CEM cell lines | Homo sapiens | - |
| RAJI cell | - |
Homo sapiens | - |
| RPMI-8226 cell | - |
Homo sapiens | - |
| THP-1 cell | - |
Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, however enzyme activity in RPMI 8226 cells destroyed by storage at -70°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosylceramide | - |
Homo sapiens | UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosylceramide | - |
? | |
| UDP-galactose + lactosylceramide | - |
Homo sapiens | UDP + globotriaosylceramide | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
THP-1 cells | Homo sapiens |
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