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Literature summary for 2.4.1.222 extracted from

  • Azam, S.; Akhunzada, M.
    Structure and dynamic studies of lunatic, manic and radical fringe (2013), J. Mol. Liq., 188, 186-195.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
gene Lfng, Lfng is located at 7p22 arm of human chromosome Homo sapiens
gene Mfng, Mfng maps to human chromosome 22q13.1 Homo sapiens
gene Rfng, Rfng is localized at 17q25 arm of human chromosome Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular fringe is a secreted protein Homo sapiens
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme transfers beta-D-N-acetylglucosaminyl residues to EGF repeats of Notch proteins, Notch receptors and ligands are transmembrane proteins ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00587 gene MFNG
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Homo sapiens Q8NES3 gene lfng
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Homo sapiens Q9Y644 gene Rfng
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme transfers beta-D-N-acetylglucosaminyl residues to EGF repeats of Notch proteins, Notch receptors and ligands are transmembrane proteins Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More enzyme structure homology modelling using Mus musculus manic fringe crystal structure, PDB ID 2J0A, as template, comparison with the other human fringe enzymes, overview Homo sapiens

Synonyms

Synonyms Comment Organism
Fringe
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Homo sapiens
Lunatic Fringe
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Homo sapiens
Manic fringe
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Homo sapiens
O-fucosylpeptide-3-beta-N-acetylglucosaminyltransferase
-
Homo sapiens
Radical Fringe
-
Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme belongs to the family of glycosyltransferases. Binding to UDP and presence of DxD motif are two significant characteristics of glycosyltransferases Homo sapiens
additional information enzyme structure modelling using Mus musculus manic fringe crystal structure, PDB ID 2J0A, as template, comparison with the other human fringe enzymes, overview. Homology modeling and molecular dynamics simulation, overview Homo sapiens
physiological function the enzyme adds N-acetylglucoseamine to O-linked fucose on epidermal growth factor repeats of Notch. Fringe is a Golgi resident glycosyltransferase that requires a specific DxD active site motif to function. It specifically binds to uridinediphosphate (UDP) Homo sapiens