Cloned (Comment) | Organism |
---|---|
gene Lfng, Lfng is located at 7p22 arm of human chromosome | Homo sapiens |
gene Mfng, Mfng maps to human chromosome 22q13.1 | Homo sapiens |
gene Rfng, Rfng is localized at 17q25 arm of human chromosome | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | fringe is a secreted protein | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme transfers beta-D-N-acetylglucosaminyl residues to EGF repeats of Notch proteins, Notch receptors and ligands are transmembrane proteins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00587 | gene MFNG | - |
Homo sapiens | Q8NES3 | gene lfng | - |
Homo sapiens | Q9Y644 | gene Rfng | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme transfers beta-D-N-acetylglucosaminyl residues to EGF repeats of Notch proteins, Notch receptors and ligands are transmembrane proteins | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme structure homology modelling using Mus musculus manic fringe crystal structure, PDB ID 2J0A, as template, comparison with the other human fringe enzymes, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Fringe | - |
Homo sapiens |
Lunatic Fringe | - |
Homo sapiens |
Manic fringe | - |
Homo sapiens |
O-fucosylpeptide-3-beta-N-acetylglucosaminyltransferase | - |
Homo sapiens |
Radical Fringe | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the family of glycosyltransferases. Binding to UDP and presence of DxD motif are two significant characteristics of glycosyltransferases | Homo sapiens |
additional information | enzyme structure modelling using Mus musculus manic fringe crystal structure, PDB ID 2J0A, as template, comparison with the other human fringe enzymes, overview. Homology modeling and molecular dynamics simulation, overview | Homo sapiens |
physiological function | the enzyme adds N-acetylglucoseamine to O-linked fucose on epidermal growth factor repeats of Notch. Fringe is a Golgi resident glycosyltransferase that requires a specific DxD active site motif to function. It specifically binds to uridinediphosphate (UDP) | Homo sapiens |