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Literature summary for 2.4.1.222 extracted from

  • Zhang, S.; Chung, W.C.; Wu, G.; Egan, S.E.; Miele, L.; Xu, K.
    Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction (2015), Cancer Res., 75, 1936-1943.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme modifies EGF repeats in the Notch extracellular domain ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00587 gene MFNG
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell manic fringe is highly expressed in claudin-low breast cancer Homo sapiens
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mammary gland
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 Homo sapiens
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MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme modifies EGF repeats in the Notch extracellular domain Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Manic fringe
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 Homo sapiens
MFng
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 Homo sapiens

General Information

General Information Comment Organism
malfunction Mfng silencing in claudin-low breast cancer CLBC cell lines reduces cell migration, tumorsphere formation, and in vivo tumorigenicity associated with a decrease in the stem-like cell population. Lfng deficiency induces basal-like breast cancer Homo sapiens
physiological function manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated phosphoinositide kinase PIK3CG induction. The enzyme functions as an oncogen in claudin-low breast cancer. Phosphoinossitide kinase Pik3cg is a direct target of enzyme Mfng-enhanced Notch signaling in claudin-low breast cancer Homo sapiens