Literature summary for 2.4.1.221 extracted from

Lopaticki, S.; Yang, A.S.P.; John, A.; Scott, N.E.; Lingford, J.P.; ONeill, M.T.; Erickson, S.M.; McKenzie, N.C.; Jennison, C.; Whitehead, L.W.; Douglas, D.N.; Kneteman, N.M.; Goddard-Borger, E.D.; Boddey, J.A.
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts (2017), Nat. Commun., 8, 561 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Plasmodium falciparum	5783	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
59000	-	calculated from sequence	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q8I360	isolate 3D7	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-L-fucose + protein	-	Plasmodium falciparum	GDP + fucosylated protein	-	?

Synonyms

Synonyms	Comment	Organism
GDP-fucose protein O-fucosyltransferase 2	-	Plasmodium falciparum
POFUT2	-	Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Plasmodium falciparum

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Plasmodium falciparum

General Information

General Information	Comment	Organism
malfunction	genetic disruption of POFUT2 in Plasmodium falciparum results in ookinetes that are attenuated for colonizing the mosquito midgut, an essential step in malaria transmission. Some POFUT2-deficient parasites mature into salivary gland sporozoites although they are impaired for gliding motility, cell traversal, hepatocyte invasion, and production of exoerythrocytic forms in humanized chimeric liver mice	Plasmodium falciparum
physiological function	the enzyme is responsible for O-glycosylating of the sporozoite surface proteins CSP and TRAP. The enzyme (POFUT2) ensures the trafficking of Plasmodium thrombospondin repeat proteins as part of a non-canonical glycosylation-dependent endoplasmic reticulum protein quality control mechanism	Plasmodium falciparum

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Release 2023.1 (January 2023)