Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | OFUT1 may be a chaperone of Notch that is necessary for retaining Notch at the cell surface once it has traversed the secretory pathway | Drosophila sp. (in: flies) | 9986 | - |
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
endoplasmic reticulum | OFUT1 may be a chaperone of Notch that is necessary for escorting Notch out of the endoplasmic reticulum | Drosophila sp. (in: flies) | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Drosophila sp. (in: flies) | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
embryonic stem cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GDP-L-fucose + Notch | Pofut1 transfers fucose in the endoplasmic reticulum, transfers fucose to Ser or Thr residues of epidermal growth factor-like repeats | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
O-fucosyltransferase 1 | - |
Cricetulus griseus |
O-fucosyltransferase 1 | - |
Drosophila sp. (in: flies) |
O-fucosyltransferase 1 | - |
Mus musculus |
OFUT1 | - |
Drosophila sp. (in: flies) |
Pofut1 | - |
Cricetulus griseus |
Pofut1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | CHO cells lacking Pofut1 express Notch receptors on the cell surface at similar levels to wild-type cells | Cricetulus griseus |
malfunction | deletion of Pofut1 leads to global defects in Notch signaling and death of mice at E9.5, with a phenotype consistent with inactivation of signaling by the four Notch receptors. Embryonic stem cells lacking Pofut1 express Notch receptors on the cell surface at similar levels to wild-type cells. In mouse somites, there is evidence of altered Notch trafficking in the absence of Pofut1, consistent with reduced cell surface expression | Mus musculus |