Application | Comment | Organism |
---|---|---|
molecular biology | O-fucosylation is dispensable for many Notch signaling events during Drosophila development | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
R254A | expression of a mutant, Ofut1R245A, lacking fucosyltransferase activity, rescues the requirement for Ofut1 in embryonic neurogenesis. Lack of requirement for O-fucosylation is further supported by the absence of embryonic phenotypes in Gmd mutants, which lack all forms of fucosylation. Requirements for O-fucose during imaginal development are evaluated by characterizing clones of cells expressing only Ofut1R245A. These clones phenocopy fringe mutant clones, indicating that the absence of O-fucose is functionally equivalent to the absence of elongated O-fucose | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
O-fucosyltransferase 1 | - |
Drosophila melanogaster |
OFUTI | - |
Drosophila melanogaster |