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Literature summary for 2.4.1.214 extracted from

  • Wagers, A.J.; Kansas, G.S.
    Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta1 through a p38 mitogen-activated protein kinase-dependent pathway (2000), J. Immunol., 165, 5011-5016.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information interleukin-12 i.e. IL-12, and TGF-beta1 strongly induce the enzyme in activated T-cells, IL-12 and TGF-beta1 are important for homing of the T-cells to inflammation sites in the skin and gut, respectively, via selectins, which are bound by ligands expressed by the T-cells involving the enzyme, induction by TGF-beta1 can be blocked by p38 mitogen-activated protein kinase, but is unaffected by mitogen-activated protein/extracellular signal-related kinase kinase inhibitor, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is essential for biosynthesis of selectin binding ligands in T-cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
-
Homo sapiens
-
gut
-
Homo sapiens
-
leukocyte buffy coat Homo sapiens
-
additional information IL-12 and TGF-beta1 are important for homing of the T-cells to inflammation sites in the skin and gut, respectively, via selectins, which are bound by ligands expressed by the T-cells involving the enzyme Homo sapiens
-
peripheral blood mononuclear cell CD4+ cell Homo sapiens
-
skin
-
Homo sapiens
-
T-lymphocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is essential for biosynthesis of selectin binding ligands in T-cells Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
alpha(1,3)-fucosyltransferase VII
-
Homo sapiens
FucT-VII
-
Homo sapiens