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Literature summary for 2.4.1.212 extracted from

  • Ruegheimer, L.; Olerud, J.; Johnsson, C.; Takahashi, T.; Shimizu, K.; Hansell, P.
    Hyaluronan synthases and hyaluronidases in the kidney during changes in hydration status (2009), Matrix Biol., 28, 390-395.
    View publication on PubMed
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Application

Application Comment Organism
medicine HAS 2 appears to be a major contributor to the baseline levels of hyaluronan. Reduced HAS 2 gene expression and increased excreted urinary hyaluronidase activity during dehydration contribute to the reduced amount of hyaluronan and to antidiuretic response. In hydrated animals, the diuretic response is followed by a 58% elevation in papillary hyaluronan and a 45% reduction in the excreted urinary hyaluronidase activity. No difference is determined in HAS 1–3 mRNA or HYAL 1, 3–4 mRNA expression. In dehydrated animals, antidiuresis is followed by a 22% reduction in papillary hyaluronan and a 62% elevation in excreted urinary hyaluronidase activity. Plasma vasopressin is 2.8-fold higher in dehydrated versus hydrated rats Rattus norvegicus
medicine in hydrated animals, the diuretic response is followed by a 58% elevation in papillary hyaluronan and a 45% reduction in the excreted urinary hyaluronidase activity. No difference is determined in HAS 1–3 mRNA or HYAL 1, 3–4 mRNA expression. In dehydrated animals, antidiuresis is followed by a 22% reduction in papillary hyaluronan and a 62% elevation in excreted urinary hyaluronidase activity. Plasma vasopressin is 2.8-fold higher in dehydrated versus hydrated rats Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Rattus norvegicus O35776 isoform HAS2
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Source Tissue

Source Tissue Comment Organism Textmining
kidney strong expression of HAS2 mRNA Rattus norvegicus
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kidney weak expression of HAS1 and HAS3 mRNA Rattus norvegicus
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Expression

Organism Comment Expression
Rattus norvegicus reduced HAS 2 gene expression and increased excreted urinary hyaluronidase activity during dehydration contribute to the reduced amount of hyaluronan and to antidiuretic response down