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Literature summary for 2.4.1.212 extracted from

  • David-Raoudi, M.; Deschrevel, B.; Leclercq, S.; Galera, P.; Boumediene, K.; Pujol, J.P.
    Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt (2009), Arthritis Rheum., 60, 760-770.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens O00219 isoform HAS3
-
Homo sapiens Q92819 isoform HAS2
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Homo sapiens Q92839 isoform HAS1
-

Source Tissue

Source Tissue Comment Organism Textmining
synoviocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Has2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens chondroitin sulfate increases hyaluronan production by osteoarthritic fibroblast-like synoviocytes through up-regulation of the expression of HAS1 and HAS2 associated with activation of ERK-1/2, p38, and Akt, although to a lesser extent. Both p38 and Akt are involved in chondroitin sulfate-induced hyaluronan accumulation. IL-1 increases hyaluronan production and levels of mRNA for HAS1, HAS2, and HAS3. Chondroitin sulfate enhances the IL-1induced level of HAS2 mRNA and reduces the level of HAS3 mRNA. IL-1induced activation of p38 and JNK is slightly decreased by chondroitin sulfate, whereas that of ERK-1/2 and Akt is enhanced. More high molecular weight hyaluronan is found in chondroitin sulfate plus IL-1treated fibroblast-like synoviocytes than in fibroblast-like synoviocytes treated with IL-1 alone up