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Literature summary for 2.4.1.212 extracted from

  • Tracy, B.S.; Avci, F.Y.; Linhardt, R.J.; DeAngelis, P.L.
    Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans (2007), J. Biol. Chem., 282, 337-344.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
synthesis it may be possible to generate compounds that will selectively inhibit the binding of hyaluronan to one particular hyaladherin species without perturbing other species. Such sugar molecules may have future utility as selective therapeutics with minimal side effects for diseases such as cancer, autoimmune disease, inflammation, and infection Pasteurella multocida

Organism

Organism UniProt Comment Textmining
Pasteurella multocida
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PmHAS elongates a range of acceptor molecules in addition to the cognate sugars. Certain glycosaminoglycans are very poor acceptors in comparison to the cognate molecules, but elongated products are detected. The interaction between the acceptor and the enzyme (a) the orientation of the hydroxyl at the C-4 position of the hexosamine is not critical, (b) the conformation of C-5 of the hexuronic acid (glucuronic versus iduronic) is not crucial, and (c) additional negative sulfate groups are well tolerated in certain cases, such as on C-6 of the hexosamine, but others, including C-4 sulfates, are not or are poorly tolerated Pasteurella multocida ?
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UDP-D-glucuronate + chondroitin 4-sulfate trisaccharide 3.6% of the activity with hyaluronan Pasteurella multocida ?
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UDP-D-glucuronate + chondroitin 6-sulfate pentasaccharide 61% of the activity with hyaluronan Pasteurella multocida ?
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UDP-D-glucuronate + chondroitin 6-sulfate trisaccharide 80% of the activity with hyaluronan Pasteurella multocida ?
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UDP-D-glucuronate + chondroitin sulfate 12% of the activity with hyaluronan Pasteurella multocida ?
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UDP-D-glucuronate + unsulfated chondroitin 54% of the activity with hyaluronan Pasteurella multocida ?
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 ?

Synonyms

Synonyms Comment Organism
PmHAS
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 Pasteurella multocida