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Literature summary for 2.4.1.206 extracted from

  • Chou, D.K.H.; Jungalwala, F.B.
    N-acetylglucosaminyltransferase regulates the expression of neolactoglycolipids including sulfoglucuronylglycolipids in the developing nervous system (1993), J. Biol. Chem., 268, 21727-21733.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
CHAPS 41% stimulation compared to Triton CF-54 Rattus norvegicus
deoxycholate 8% stimulation compared to Triton CF-54 Rattus norvegicus
octyl-beta-D-glucopyranoside 46% stimulation compared to Triton CF-54 Rattus norvegicus
sodium taurocholate 25% stimulation compared to Triton CF-54 Rattus norvegicus
taurodeoxycholate 11% stimulation compared to Triton CF-54 Rattus norvegicus
Triton CF-54 stimulation, maximal at 0.4% Rattus norvegicus
Triton X-100 89% stimulation compared to Triton CF-54 Rattus norvegicus
Tween 20 38% stimulation compared to Triton CF-54 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.021
-
D-galactosyl-1,4-beta-D-glucosylceramide cerebellum microsomes Rattus norvegicus
0.035
-
D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide cerebellum microsomes Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 78% activity compared to Mn2+ Rattus norvegicus
Cu2+ 4% activity compared to Mn2+ Rattus norvegicus
Hg2+ 4% activity compared to Mn2+ Rattus norvegicus
Mg2+ 40% activity compared to Mn2+ Rattus norvegicus
Mn2+ absolute requirement Rattus norvegicus
Zn2+ 11% activity compared to Mn2+ Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + lactosylceramide Rattus norvegicus biosynthetic pathway of lactoseries and ganglioseries UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley albino
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
cerebellum neonatal Rattus norvegicus
-
cerebral cortex fetal Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide i.e. lactosylceramide Rattus norvegicus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
?
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-phenyl-C14H29 synthetic substrate, 75% specific activity compared to lactosylceramide Rattus norvegicus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-phenyl-C14H29
-
?
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
Rattus norvegicus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
?
UDP-N-acetyl-D-glucosamine + lactosylceramide biosynthetic pathway of lactoseries and ganglioseries Rattus norvegicus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.8 7.4 cacodylate buffer Rattus norvegicus