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Literature summary for 2.4.1.198 extracted from

  • Murata, D.; Nomura, K.H.; Dejima, K.; Mizuguchi, S.; Kawasaki, N.; Matsuishi-Nakajima, Y.; Ito, S.; Gengyo-Ando, K.; Kage-Nakadai, E.; Mitani, S.; Nomura, K.
    GPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans (2012), Mol. Biol. Cell, 23, 982-995.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
genes involved in GPI-anchor synthesis in Caenorhabditis elegans, overview. Isolation and analysis of piga-1-knockout allele tm2939 Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information the RNAi phenotypes of each gene, including larval arrest, scrawny larvae, and germline defects, may result from N-/O-glycosylation inhibition as well as GPI-anchor inhibition Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol Caenorhabditis elegans
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 UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
 gene piga-1 encoding the catalytic subunit of the phosphatidylinositol N-acetylglucosaminyltransferase complex
-

Source Tissue

Source Tissue Comment Organism Textmining
germ cell
-
 Caenorhabditis elegans
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gonad
-
 Caenorhabditis elegans
-
additional information the wild-type PIGA-1 protein is solely detected in the germline, and no EGFP-tagged PIGA-1 is detected in so­matic cells Caenorhabditis elegans
-
muscle
-
 Caenorhabditis elegans
-
neuron
-
 Caenorhabditis elegans
-
oocyte
-
 Caenorhabditis elegans
-
sperm
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol
-
 Caenorhabditis elegans UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
 ?

Synonyms

Synonyms Comment Organism
glycosylphosphatidylinositol N-acetylglucosaminyltrans­ferase complex
-
 Caenorhabditis elegans
GPI-GnT
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction piga-1-knockout worms show 100% lethality, with decreased mitotic germline cells and abnormal eggshell formation. Cell-specific rescue of the null allele, expression of piga-1 in somatic gonads and/or in germline is sufficient for normal embryonic development and the maintenance of the germline mitotic cells. The RNAi phenotypes of each gene, including larval arrest, scrawny larvae, and germline defects, may result from N-/O-glycosylation inhibition as well as GPI-anchor inhibition Caenorhabditis elegans
physiological function the phosphatidylinositol N-acetylglucosaminyltransferase complex catalyzes the first step of GPI-anchor syn­thesis, which is indispensable for the germline development of the nematode Caenorhabditis elegans. GPI-anchor synthesis is indispens­able for the maintenance of mitotic germline cell number Caenorhabditis elegans