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Literature summary for 2.4.1.198 extracted from
- Inhibition of the GlcNAc transferase of the glycosylphosphatidylinositol anchor biosynthesis in African trypanosomes (1992), Eur. J. Biochem., 208, 309-314.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetic acid | - |
Trypanosoma brucei |  |
| N-ethylmaleimide | binding site is close or at the active site, UDP-N-acetyl-D-glucosamine protects; strong | Trypanosoma brucei | |
| p-chloromercuriphenylsulfonic acid | - |
Trypanosoma brucei | |
| SH-alkylating reagents | - |
Trypanosoma brucei |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Trypanosoma brucei | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + phosphatidylinositol | Trypanosoma brucei | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | - |
variant MITat 1.4 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + phosphatidylinositol | - |
Trypanosoma brucei | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | in alpha1-6 linkage | ? | |
| UDP-N-acetyl-D-glucosamine + phosphatidylinositol | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | Trypanosoma brucei | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Trypanosoma brucei |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Trypanosoma brucei |
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Release 2023.1 (January 2023)
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