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Literature summary for 2.4.1.175 extracted from

  • Momose, T.; Yoshimura, Y.; Harumiya, S.; Isobe, K.; Kito, M.; Fukushima, M.; Kato, H.; Nakayama, J.
    Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance (2016), Hum. Pathol., 50, 15-23.
    View publication on PubMed
Search for more literature for 2.4.1.175

Application

Application Comment Organism
diagnostics chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance. High expression of CHSY1 is significantly associated with poorer patient outcomes Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene CHSY1, quantitative reverse-transcription PCR enzyme expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan Homo sapiens
-
 UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86X52 gene CHSY1
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
-
 Homo sapiens
-
additional information enzyme CHSY1 is strongly expressed in myxofibrosarcoma and malignant peripheral nerve sheath tumor compared with other tumors and significantly associated with higher rather than lower grade tumors, mmunohistochemic analysis, overview Homo sapiens
-
sarcoma cell soft tissue sarcomas with myxoid substance: myxoid liposarcoma, 14 of myxofibrosarcoma, 12 of malignant peripheral nerve sheath tumor, and 2 of low-grade fibromyxoid sarcoma. Soft tissue sarcoma is a malignant tumor of nonepithelial extraskeletal origin classified by specific, differentiated cell types Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
-
 Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
-
 ?

Synonyms

Synonyms Comment Organism
chondroitin sulfate synthase 1
-
 Homo sapiens
CHSY1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function chondroitin sulfate synthase 1 (CHSY1) is the key biosynthetic enzyme forming the repeating chondroitin sulfate backbone disaccharide structure [4GlcAbeta1-3GalNAcbeta1], and polymerization of chondroitin chain by CHSY1 requires chondroitin polymerizing factors, including CHPF and CHPF2. The bifunctional enzyme CHSY1 exhibits both GlcAT-II and GalNAc-II activities Homo sapiens