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Literature summary for 2.4.1.175 extracted from

  • Gotoh, M.; Sato, T.; Akashima, T.; Iwasaki, H.; Kameyama, A.; Mochizuki, H.; Yada, T.; Inaba, N.; Zhang, Y.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Nishihara, S.; Watanabe, H.; Kimata, K.; Narimatsu, H.
    Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis (2002), J. Biol. Chem., 277, 38189-38196.
    View publication on PubMed
Search for more literature for 2.4.1.175

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis, expression of a truncated form, consisting of the putative catalytic domain, in Spodoptera frugiperda Sf21 insect cells as a soluble FLAG-tagged protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TDX6 chondroitin sulfate N-acetylgalactosaminyltransferase
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland low content Homo sapiens
-
bone marrow
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
cerebral cortex
-
 Homo sapiens
-
colon low content Homo sapiens
-
G-361 cell melanoma cell line Homo sapiens
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kidney very low content Homo sapiens
-
leukocyte low content Homo sapiens
-
liver very low content Homo sapiens
-
lung low content Homo sapiens
-
ovary
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta very high content Homo sapiens
-
small intestine high content Homo sapiens
-
spleen
-
 Homo sapiens
-
SW-1736 cell thyroid cancer cell line Homo sapiens
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testis low content Homo sapiens
-
thymus low content Homo sapiens
-
thyroid gland very high content Homo sapiens
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U266 cell myeloma cell line Homo sapiens
-
uterus
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information low activity with sulfated oligosaccharide substrates Homo sapiens ?
-
 ?
additional information chondroitin sulfates A, C, D, and E, and dermatan sulfate are poor acceptor substrates Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
-
 Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
-
 Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
-
 Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
-
 Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)7
-
 Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
-
 ?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide low activity Homo sapiens UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
 ?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide acceptors are even-numbered chondroitin oligosaccharides with terminal glucuronyl-N-acetyl-1,3-beta-D-galactosamine sequence at non-reducing end, transfers N-acetyl-galactosamine to non-reducing glucuronic acid residues in beta-glycosidic linkage Homo sapiens UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
 ?
UDP-N-acetyl-D-galactosamine + chondroitin polysaccharide best acceptor substrate Homo sapiens UDP + N-acetyl-D-galactosaminyl chondroitin polysaccharide
-
 ?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
-
 Homo sapiens UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
-
 ?

Synonyms

Synonyms Comment Organism
More the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174 Homo sapiens
More the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli. Homo sapiens