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Literature summary for 2.4.1.174 extracted from

  • Sato, T.; Kudo, T.; Ikehara, Y.; Ogawa, H.; Hirano, T.; Kiyohara, K.; Hagiwara, K.; Togayachi, A.; Ema, M.; Takahashi, S.; Kimata, K.; Watanabe, H.; Narimatsu, H.
    Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism (2011), J. Biol. Chem., 286, 5803-5812.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.174

Protein Variants

Protein Variants Comment Organism
additional information generation of Csgalnact1-/- mice by using a targeting vector for Csgalnact1 gene disruption Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan Mus musculus
-
 UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan Mus musculus C57/BL6J
-
 UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57/BL6J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain quantitative analysis of Csgalnact1 and Csgalnact2 transcripts in brain of wild-type and Csgalnact1-/- mice by real-time PCR, overview Mus musculus
-
cartilage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
-
 Mus musculus UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
-
 Mus musculus C57/BL6J UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?

Synonyms

Synonyms Comment Organism
chondroitin sulfate N-acetylgalactosaminyltransferase 1
-
 Mus musculus
CSGalNAcT-1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the growth plate of Csgalnact1-/- mice contains shorter and slightly disorganized chondrocyte columns with a reduced volume of the extracellular matrix principally in the proliferative layer. Immunohistochemical analysis reveals that the level of both aggrecan and link protein 1 are decreased in Csgalnact1-/- cartilage with an increase in processed forms of aggrecan core protein, phenotype, overview Mus musculus
metabolism chondroitin sulfate biosynthetic pathway and relevant glycosyltransferases, overview Mus musculus
physiological function chondroitin sulfate N-acetylgalactosaminyltransferase 1, CSGalNAcT-1, participates in the chondroitin sulfate chain initiation and is necessary for normal endochondral ossification and aggrecan metabolism Mus musculus