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Literature summary for 2.4.1.174 extracted from
- Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning (2012), Dev. Biol., 363, 413-425.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
| skeletal system | expression of Chsy1 is up-regulated in skeletal elements | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chondroitin sulfate synthase 1 | - |
Mus musculus |
| CHSY1 | - |
Mus musculus |
| CSS1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Chsy1-/- mice show a profound limb patterning defect in which orthogonally shifted ectopic joints form in the distal digits. Associated with the digit-patterning defect is a shift in cell orientation and an imbalance in chondroitin sulfation. Chondrogenesis is impaired as early as E13.5 in Chsy1-/- embryos. Ectopic, split digit phenotype, overview | Mus musculus |
| physiological function | Chsy1 catalyzes the extension of chondroitin and dermatan sulfate glycosaminoglycans and is an essential regulator of joint patterning | Mus musculus |
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Release 2023.1 (January 2023)
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