Literature summary for 2.4.1.17 extracted from

Zhang, Q.; Cao, Y.F.; Ran, R.X.; Li, R.S.; Wu, X.; Dong, P.P.; Zhang, Y.Y.; Hu, C.M.; Wang, W.M.
Strong specific inhibition of UDP-glucuronosyltransferase 2B7 by atractylenolide I and III (2016), Phytother. Res., 30, 25-30.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one	i.e. atractylenolide II, one of two important efficient herbal ingredients isolated from Atractylodes macrocepha exhibits specific inhibition towards UGT2B7, with negligible influence towards other UGT isoforms	Homo sapiens
(8aS)-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one	i.e. atractylenolide I, one of two important efficient herbal ingredients isolated from Atractylodes macrocephala, exhibits specific competitive inhibition towards UGT2B7, with negligible influence towards other UGT isoforms	Homo sapiens
additional information	in silico docking and molecular homology modeling for inhibition mechanism elucidation. Atractylenolide I exerts stronger inhibition potential than atractylenolide III towards UGT2B7, which is attributed to the different hydrogen bonds and hydrophobic interactions. Inhibition kinetic analysis for the inhibition of atractylenolide I towards UGT2B7 reveals competitive inhibition by atractylenolide I	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16662	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucuronate + 4-methylumbelliferone	-	Homo sapiens	UDP + 4-methylumbelliferyl-beta-D-glucuronoside	-	?

Synonyms

Synonyms	Comment	Organism
UDP-glucuronosyltransferase 2B7	-	Homo sapiens
UGT2B7	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	inhibition kinetic analysis	Homo sapiens

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Release 2023.1 (January 2023)