Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gossypol | noncompetitive inhibitin of estradiol-3-glucuronidation and propofol O-glucuronidation, competitive inhibition towards 3'-azido-3'-deoxythymidine glucuronidation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate | substrate of isoform UGT2B7 | Homo sapiens | 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP | - |
? | |
estradiol + UDP-alpha-D-glucuronate | substrate of isoform UGT1A1 | Homo sapiens | UDP + estradiol 3-O-glucuronide | - |
? | |
propofol + UDP-alpha-D-glucuronate | substrate of isoform UGT1A9 | Homo sapiens | UDP + propofol D-glucuronide | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0164 | - |
gossypol | substrate propofol, pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0342 | - |
gossypol | substrate estradiol, pH 7.4, temperature not specified in the publication | Homo sapiens |