Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Src | overexpression of regular or active Src, but not dominant-negative Src, in UGT2B7-transfected COS-1 cells increases UGT2B7 activity and phospho-Y438-2B7 by 50%. UGT2B7 and regular SrcTK are co-localized in COS-1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | UGT2B7 mutants at protein kinase C-sites have essentially normal activity | Homo sapiens |
S132A | protein kinase C-site mutant, activity similar to wild-type | Homo sapiens |
S132A/S437A | protein kinase C-site mutant, activity similar to wild-type | Homo sapiens |
S437A | protein kinase C-site mutant, activity similar to wild-type | Homo sapiens |
T123A | protein kinase C-site mutant, activity similar to wild-type | Homo sapiens |
T123A/S132A | protein kinase C-site mutant, activity similar to wild-type | Homo sapiens |
T123A/S132A/S437A | protein kinase C-site mutant, activity similar to wild-type | Homo sapiens |
T123A/S437A | protein kinase C-site mutant, activity similar to wild-type | Homo sapiens |
Y236F | tyrosine kinase-sites mutants, inactive | Homo sapiens |
Y438F | tyrosine kinase-sites mutants, inactive | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform UGT2B7 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17-epiestriol + UDP-glucuronate | - |
Homo sapiens | UDP + ? | - |
? | |
4-hydroxyestrone + UDP-glucuronate | - |
Homo sapiens | UDP + 4-hydroxyestrone 4-O-glucuronide | - |
? |