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Literature summary for 2.4.1.17 extracted from
- Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10 (2007), Mol. Pharmacol., 72, 761-768.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of isozyme UGT1A4 in Spodoptera frugiperda Sf9 cell microsomal membranes, expression analysis, overview | Homo sapiens |
| expression of isozyme UGT2B10 in Spodoptera frugiperda Sf9 cell microsomal membranes, expression analysis, overview | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | isozyme UGT1A4 with substrates nicotine and cotinine in liver and intestine microsomes | Homo sapiens | |
| additional information | - |
additional information | isozyme UGT2B10 with substrates nicotine and cotinine in liver and intestine microsomes | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + cotinine | Homo sapiens | isozyme UGT2B10, cotinine is exclusively glucuronized in liver, no activity in intestinal microsomes | UDP + ? | - |
? | |
| UDP-D-glucuronate + nicotine | Homo sapiens | isozyme UGT2B10, nicotine is mainly glucuronized in liver, very low activity in intestinal microsomes | UDP + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P22310 | isozyme UGT1A4; isozyme UGT1A4 | - |
| Homo sapiens | P36537 | isozyme UGT2B10; isozyme UGT2B10 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | isozyme UGT2B10 is exclusively expressed in liver | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + cotinine | isozyme UGT1A4 | Homo sapiens | UDP + ? | - |
? | |
| UDP-D-glucuronate + cotinine | isozyme UGT2B10, cotinine is exclusively glucuronized in liver, no activity in intestinal microsomes | Homo sapiens | UDP + ? | - |
? | |
| UDP-D-glucuronate + cotinine | isozyme UGT2B10 | Homo sapiens | UDP + ? | - |
? | |
| UDP-D-glucuronate + nicotine | isozyme UGT1A4 | Homo sapiens | UDP + ? | - |
? | |
| UDP-D-glucuronate + nicotine | isozyme UGT2B10, nicotine is mainly glucuronized in liver, very low activity in intestinal microsomes | Homo sapiens | UDP + ? | - |
? | |
| UDP-D-glucuronate + nicotine | isozyme UGT2B10 | Homo sapiens | UDP + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
| UGT1A4 | - |
Homo sapiens |
| UGT2B10 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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