KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + 4'-hydroxy-warfarin | Homo sapiens | substrate of isozyme UGT1A10 | UDP + 4'-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 6-hydroxy-warfarin | Homo sapiens | substrate of isozyme UGT1A1 | UDP + 6-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 6-hydroxy-warfarin | Homo sapiens | substrate of isozyme UGT1A10 | UDP + 6-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 7-hydroxy-warfarin | Homo sapiens | substrate of isozyme UGT1A1 | UDP + 7-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 7-hydroxy-warfarin | Homo sapiens | substrate of isozyme UGT1A10 | UDP + 7-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 8-hydroxy-warfarin | Homo sapiens | substrate of isozyme UGT1A1 | UDP + 8-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 8-hydroxy-warfarin | Homo sapiens | substrate of isozyme UGT1A10 | UDP + 8-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 8-hydroxy-warfarin | Homo sapiens | substrate of isozyme UGT1A9 | UDP + 8-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P22309 | isozyme UGT1A1; isozyme UGT1A1 | - |
Homo sapiens | Q9HAW8 | isozyme UGT1A10; isozyme UGT1A10 | - |
Homo sapiens | Q9HAW9 | isozyme UGT1A9; isozyme UGT1A9 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate specificity, UGT1A1 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview | Homo sapiens | ? | - |
? | |
additional information | substrate specificity, UGT1A10 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview | Homo sapiens | ? | - |
? | |
additional information | substrate specificity, UGT1A8, UGT1A4, UGT1A6, UGT1A7, and UGT2B7 do not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview | Homo sapiens | ? | - |
? | |
additional information | substrate specificity, UGT1A9 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview | Homo sapiens | ? | - |
? | |
UDP-D-glucuronate + 4'-hydroxy-warfarin | substrate of isozyme UGT1A10 | Homo sapiens | UDP + 4'-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 6-hydroxy-warfarin | substrate of isozyme UGT1A1 | Homo sapiens | UDP + 6-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 6-hydroxy-warfarin | substrate of isozyme UGT1A10 | Homo sapiens | UDP + 6-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 7-hydroxy-warfarin | substrate of isozyme UGT1A1 | Homo sapiens | UDP + 7-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 7-hydroxy-warfarin | substrate of isozyme UGT1A10 | Homo sapiens | UDP + 7-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 8-hydroxy-warfarin | substrate of isozyme UGT1A1 | Homo sapiens | UDP + 8-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 8-hydroxy-warfarin | substrate of isozyme UGT1A10 | Homo sapiens | UDP + 8-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 8-hydroxy-warfarin | substrate of isozyme UGT1A9 | Homo sapiens | UDP + 8-hydroxy-warfarin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |