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Literature summary for 2.4.1.17 extracted from

  • Zielinska, A.; Lichti, C.F.; Bratton, S.; Mitchell, N.C.; Gallus-Zawada, A.; Le, V.H.; Finel, M.; Miller, G.P.; Radominska-Pandya, A.; Moran, J.H.
    Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases (2008), J. Pharmacol. Exp. Ther., 324, 139-148.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-D-glucuronate + 4'-hydroxy-warfarin Homo sapiens substrate of isozyme UGT1A10 UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 6-hydroxy-warfarin Homo sapiens substrate of isozyme UGT1A1 UDP + 6-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 6-hydroxy-warfarin Homo sapiens substrate of isozyme UGT1A10 UDP + 6-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 7-hydroxy-warfarin Homo sapiens substrate of isozyme UGT1A1 UDP + 7-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 7-hydroxy-warfarin Homo sapiens substrate of isozyme UGT1A10 UDP + 7-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin Homo sapiens substrate of isozyme UGT1A1 UDP + 8-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin Homo sapiens substrate of isozyme UGT1A10 UDP + 8-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin Homo sapiens substrate of isozyme UGT1A9 UDP + 8-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + acceptor Homo sapiens
-
UDP + acceptor beta-D-glucuronoside
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P22309 isozyme UGT1A1; isozyme UGT1A1
-
Homo sapiens Q9HAW8 isozyme UGT1A10; isozyme UGT1A10
-
Homo sapiens Q9HAW9 isozyme UGT1A9; isozyme UGT1A9
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificity, UGT1A1 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview Homo sapiens ?
-
?
additional information substrate specificity, UGT1A10 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview Homo sapiens ?
-
?
additional information substrate specificity, UGT1A8, UGT1A4, UGT1A6, UGT1A7, and UGT2B7 do not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview Homo sapiens ?
-
?
additional information substrate specificity, UGT1A9 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview Homo sapiens ?
-
?
UDP-D-glucuronate + 4'-hydroxy-warfarin substrate of isozyme UGT1A10 Homo sapiens UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 6-hydroxy-warfarin substrate of isozyme UGT1A1 Homo sapiens UDP + 6-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 6-hydroxy-warfarin substrate of isozyme UGT1A10 Homo sapiens UDP + 6-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 7-hydroxy-warfarin substrate of isozyme UGT1A1 Homo sapiens UDP + 7-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 7-hydroxy-warfarin substrate of isozyme UGT1A10 Homo sapiens UDP + 7-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin substrate of isozyme UGT1A1 Homo sapiens UDP + 8-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin substrate of isozyme UGT1A10 Homo sapiens UDP + 8-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin substrate of isozyme UGT1A9 Homo sapiens UDP + 8-hydroxy-warfarin beta-D-glucuronoside
-
?
UDP-D-glucuronate + acceptor
-
Homo sapiens UDP + acceptor beta-D-glucuronoside
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
Homo sapiens
UGT
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens