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Literature summary for 2.4.1.17 extracted from
- The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver (2007), Drug Metab. Dispos., 35, 2040-2044.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | enzyme kinetics with substrate gemfibrozil follow Michaelis-Menten kinetics | Homo sapiens | |
| 0.0022 | - |
gemfibrozil | pH 7.5, 37°C, isozyme UGT2B7 | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + estradiol | Homo sapiens | isozymes UGT1A1 and UGT1A9 | UDP + estradiol 3-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + flurbiprofen | Homo sapiens | isozyme UGT2B7 | UDP + flurbiprofen beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + gemfibrozil | Homo sapiens | gemfibrozil is a fibrate hypolipidemic agent, isozyme UGT2B7 in the liver | UDP + gemfibrozil beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + morphine | Homo sapiens | isozyme UGT2B7 | UDP + morphine 3-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + propofol | Homo sapiens | isozymes UGT1A1 and UGT1A9 | UDP + propofol beta-D-glucuronoside | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
diverse isozymes | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + estradiol | isozymes UGT1A1 and UGT1A9 | Homo sapiens | UDP + estradiol 3-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + flurbiprofen | isozyme UGT2B7 | Homo sapiens | UDP + flurbiprofen beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + gemfibrozil | gemfibrozil is a fibrate hypolipidemic agent, isozyme UGT2B7 in the liver | Homo sapiens | UDP + gemfibrozil beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + gemfibrozil | activity with isozymes UGT1A1, UGT1A3, UGT1A9, UGT2B4, UGT2B7, UGT2B17, and especially with isozyme UGT2B7 showing the highest activity | Homo sapiens | UDP + gemfibrozil beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + morphine | isozyme UGT2B7 | Homo sapiens | UDP + morphine 3-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + propofol | isozymes UGT1A1 and UGT1A9 | Homo sapiens | UDP + propofol beta-D-glucuronoside | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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