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Literature summary for 2.4.1.17 extracted from
- Molecular cloning of the baboon UDP-glucuronosyltransferase 1A gene family: evolution of the primate UGT1 locus and relevance for models of human drug metabolism (2007), Pharmacogenet. Genomics, 17, 11-24.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK293 cells | Papio anubis |
| UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview | Papio anubis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A235V | C704T, naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| A26V | C77T, naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
| A432G | naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
| A483G | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| A498T | G1492A, naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| A58V | C173T, naturally occuring polymorphism of isozyme UGT1A2A | Papio anubis |
| A7G | C20G, naturally occuring polymorphism of isozyme UGT1A6 | Papio anubis |
| A966C | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| A966C | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| C117T | naturally occuring polymorphism of isozyme UGT1A2A | Papio anubis |
| C1494T | naturally occuring polymorphism of isozyme UGT1A1 | Papio anubis |
| C1497T | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| C1545T | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| C489T | naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
| C639T | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| C663T | naturally occuring polymorphism of isozyme UGT1A9 | Papio anubis |
| C702T | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| C966A | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
| G12C | naturally occuring polymorphism of isozyme UGT1A6 | Papio anubis |
| G1368T | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
| G174A | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| G399A | naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
| G720A | naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
| G804A | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| H225D | C673G, naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| K30N | G90C, naturally occuring polymorphism of isozyme UGT1A2A | Papio anubis |
| M214V | A640G, naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| N276S | A827G, naturally occuring polymorphism of isozyme UGT1A9 | Papio anubis |
| P219T | C655A, naturally occuring polymorphism of isozyme UGT1A6 | Papio anubis |
| R516W | C1546T, naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| R51S | G153T, naturally occuring polymorphism of isozyme UGT1A7 | Papio anubis |
| R91H | G272A, naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| T1368G | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| T1497C | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| T1545C | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
| T646C | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
| T702C | naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
| T750C | naturally occuring polymorphism of isozyme UGT1A4 | Papio anubis |
| T750C | naturally occuring polymorphism of isozyme UGT1A5A | Papio anubis |
| V24G | T71G, naturally occuring polymorphism of isozyme UGT1A6 | Papio anubis |
| V56F | G166T, naturally occuring polymorphism of isozyme UGT1A9 | Papio anubis |
| W512R | C1534T, naturally occuring polymorphism of isozyme UGT1A10A | Papio anubis |
| Y216H | T648C, naturally occuring polymorphism of isozyme UGT1A5B | Papio anubis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Papio anubis | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin | ? | - |
? |  |
| additional information | Papio anubis | glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin | ? | - |
? | |
| UDP-glucuronic acid + bilirubin | Papio anubis | - |
UDP + bilirubin-glucuronoside | - |
? | |
| UDP-glucuronic acid + bilirubin | Homo sapiens | UGT1A1 | UDP + bilirubin-glucuronoside | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes UGT1 and UGT2 | - |
| Papio anubis | Q20CK6 | - |
- |
| Papio anubis | Q20CK6 | isozyme UGT1A10B; gene UGT1A10B | - |
| Papio anubis | Q20CK7 | - |
- |
| Papio anubis | Q20CK7 | isozyme UGT1A8; gene UGT1A8 | - |
| Papio anubis | Q20CK8 | - |
- |
| Papio anubis | Q20CK8 | isozyme UGT1A10A; gene UGT1A10A | - |
| Papio anubis | Q20CK9 | - |
- |
| Papio anubis | Q20CK9 | isozyme UGT1A9; gene UGT1A9 | - |
| Papio anubis | Q20CL0 | - |
- |
| Papio anubis | Q20CL0 | isozyme UGT1A7; gene UGT1A7 | - |
| Papio anubis | Q20CL1 | - |
- |
| Papio anubis | Q20CL1 | isozyme UGT1A6; gene UGT1A6 | - |
| Papio anubis | Q20CL2 | - |
- |
| Papio anubis | Q20CL2 | isozyme UGT1A5B; gene UGT1A5B | - |
| Papio anubis | Q20CL3 | - |
- |
| Papio anubis | Q20CL3 | isozyme UGT1A5A; gene UGT1A5A | - |
| Papio anubis | Q20CL4 | - |
- |
| Papio anubis | Q20CL4 | isozyme UGT1A4; gene UGT1A4 | - |
| Papio anubis | Q20CL5 | - |
- |
| Papio anubis | Q20CL5 | isozyme UGT1A2A; gene UGT1A2A | - |
| Papio anubis | Q20CL6 | - |
- |
| Papio anubis | Q20CL6 | isozyme UGT1A1; gene UGT1A1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastrointestinal tract | isozymes UGT1 and UGT2 | Homo sapiens | - |
| ileum | - |
Papio anubis | - |
| ileum | isozyme UGT1A7 | Papio anubis | - |
| ileum | isozyme UGT1A8 | Papio anubis | - |
| ileum | isozyme UGT1A10A | Papio anubis | - |
| ileum | isozyme UGT1A10B | Papio anubis | - |
| ileum | isozyme UGT1A4 | Papio anubis | - |
| ileum | isozyme UGT1A5A | Papio anubis | - |
| ileum | isozyme UGT1A5B | Papio anubis | - |
| kidney | isozymes UGT1 and UGT2 | Homo sapiens | - |
| liver | - |
Papio anubis | - |
| liver | isozyme UGT1A1 | Papio anubis | - |
| liver | isozyme UGT1A9 | Papio anubis | - |
| liver | isozyme UGT1A2A | Papio anubis | - |
| liver | isozyme UGT1A6 | Papio anubis | - |
| liver | isozymes UGT1 and UGT2 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetaminophen + UDP-glucuronate | - |
Papio anubis | ? | - |
? | |
| additional information | glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin | Homo sapiens | ? | - |
? | |
| additional information | glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin | Papio anubis | ? | - |
? | |
| serotonin + UDP-glucuronate | - |
Papio anubis | UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide | - |
? | |
| UDP-glucuronate + 1-naphthol | - |
Papio anubis | UDP + beta-D-glucuronosyl-(1-naphthol) | - |
? | |
| UDP-glucuronate + 4-methylumbelliferone | - |
Papio anubis | UDP + beta-D-glucuronosyl-(4-methylumbelliferone) | - |
? | |
| UDP-glucuronate + 4-nitrophenol | - |
Papio anubis | UDP + 4-nitrophenyl beta-D-glucuronide | - |
? | |
| UDP-glucuronate + buprenorphine | - |
Papio anubis | UDP + buprenorphine glucuronide | - |
? | |
| UDP-glucuronic acid + bilirubin | - |
Papio anubis | UDP + bilirubin-glucuronoside | - |
? | |
| UDP-glucuronic acid + bilirubin | UGT1A1 | Homo sapiens | UDP + bilirubin-glucuronoside | - |
? | |
| UDP-glucuronic acid + bilirubin | - |
Papio anubis | bilirubin glucuronoside + UDP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | the enzyme belongs to the UDP-glucuronosyltransferase 1A gene family | Homo sapiens |
| More | the enzyme belongs to the UDP-glucuronosyltransferase 1A gene family | Papio anubis |
| UDP-glucuronosyltransferase 1A | - |
Papio anubis |
| UGT 1A1 | - |
Papio anubis |
| UGT1A10A | - |
Papio anubis |
| UGT1A10B | - |
Papio anubis |
| UGT1A2A | - |
Papio anubis |
| UGT1A4 | - |
Papio anubis |
| UGT1A5A | - |
Papio anubis |
| UGT1A5B | - |
Papio anubis |
| UGT1A6 | - |
Papio anubis |
| UGT1A7 | - |
Papio anubis |
| UGT1A8 | - |
Papio anubis |
| UGT1A9 | - |
Papio anubis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Papio anubis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Papio anubis |
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