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Literature summary for 2.4.1.17 extracted from

  • Tallman, M.N.; Ritter, J.K.; Smith, P.C.
    Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms (2005), Drug Metab. Dispos., 33, 977-983.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O60656 recombinant
-
Homo sapiens P22309
-
-
Homo sapiens Q9HAW7 recombinant
-
Homo sapiens Q9HAW9 recombinant
-
Rattus norvegicus Q64550 recombinant
-
Rattus norvegicus Q64633 recombinant
-
Rattus norvegicus Q64634 recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
-
Homo sapiens UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
-
?
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
-
Rattus norvegicus UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
-
?
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
-
Homo sapiens UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
-
?
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
-
Rattus norvegicus UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
-
?

Synonyms

Synonyms Comment Organism
UGT1A
-
Homo sapiens
UGT1A1
-
Rattus norvegicus
UGT1A7
-
Homo sapiens
UGT1A7
-
Rattus norvegicus
UGT1A8
-
Homo sapiens
UGT1A8
-
Rattus norvegicus
UGT1A9
-
Homo sapiens