Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.17 extracted from

  • Ghosh, S.S.; Lu, Y.; Lee, S.W.; Wang, X.; Guha, C.; Roy-Chowdhury, J.; Roy-Chowdhury, N.
    Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1) (2005), Biochem. J., 392, 685-692.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.17

Activating Compound

Activating Compound Comment Organism Structure
UDP-GlcNAc stimulates Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C127C mutation results in loss of UGT1A1 activity Homo sapiens
C156R mutation results in loss of UGT1A1 activity Homo sapiens
C177Y mutation results in loss of UGT1A1 activity Homo sapiens
C186C although the activity of the C186Y mutant UGT1A1 is reduced to 50% of normal, the enzyme activity increases proportionately in the presence of UDPGlcNAc Homo sapiens
C186Y 45% of wild-type activity with bilirubin as substrate Homo sapiens
C223Y mutation results in loss of UGT1A1 activity Homo sapiens
C280Y mutation results in loss of UGT1A1 activity Homo sapiens
C384Y mutation results in loss of UGT1A1 activity Homo sapiens
C509Y 75% of wild-type activity with bilirubin as substrate Homo sapiens
C510Y 80% of wild-type activity with bilirubin as substrate Homo sapiens
C517Y 85% of wild-type activity with bilirubin as substrate Homo sapiens
Q357R mutation results in loss of UGT1A1 activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P22309
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucuronate + bilirubin
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
UGT1A1
-
 Homo sapiens