Cloned (Comment) | Organism |
---|---|
expression of UGT1A and UGT2B isozymes in HEK293 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | different kinetic profiles of isozymes with different hormone substrates, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | isozymes facilitate the excretion of estrogens to glucuronides, the most abundant estrogen conjugates | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes UGT1A1, UGT1A3, UGT1A8, UGT1A9, UGT1A10, and UGT2B7 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
uterine endometrium | isozyme UGT2B7 | Homo sapiens | - |
uterus | isozyme UGT2B7 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyestrone + UDP-glucuronate | - |
Homo sapiens | UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide | - |
? | |
additional information | isozymes facilitate the excretion of estrogens to glucuronides, the most abundant estrogen conjugates | Homo sapiens | ? | - |
? | |
UDP-glucuronate + 2-hydroxyestrone | - |
Homo sapiens | UDP + 2-hydroxyestrone beta-D-glucuronide | - |
? | |
UDP-glucuronate + 2-methoxyestrone | - |
Homo sapiens | UDP + 2-methoxyestrone beta-D-glucuronide | - |
? | |
UDP-glucuronate + 4-methoxyestrone | - |
Homo sapiens | UDP + 4-methoxyestrone beta-D-glucuronide | - |
? | |
UDP-glucuronate + estradiol | - |
Homo sapiens | UDP + estradiol beta-D-glucuronide | - |
? | |
UDP-glucuronate + estrone | - |
Homo sapiens | UDP + estrone beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UGT | - |
Homo sapiens |
uridine diphosphate glucuronosyltransferase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |