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Literature summary for 2.4.1.17 extracted from
- Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism (2005), Drug Metab. Dispos., 33, 139-146.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| azidothymidine | selective for isozyme UGT2B7 | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics of microsomes from different tissues | Homo sapiens | |
| 0.16 | - |
Mycophenolic acid | isozyme UGT1A9 | Homo sapiens | |
| 0.18 | - |
Mycophenolic acid | liver microsomes | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + mycophenolic acid | Homo sapiens | mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil | UDP + mycophenolic acid-acyl-glucuronide | - |
? | |
| UDP-glucuronate + mycophenolic acid | Homo sapiens | mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil | UDP + mycophenolic acid-phenyl-glucuronide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes UGT1A9 and UGT2B7, renal transplant patients under mycopenolate mofetil therapy | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | mucosa, isozymes UGT1A9 and UGT2B7 | Homo sapiens | - |
| kidney | isozymes UGT1A9 and UGT2B7 | Homo sapiens | - |
| liver | isozymes UGT1A9 and UGT2B7 | Homo sapiens | - |
| mucosa | intestinal, isozymes UGT1A9 and UGT2B7 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + mycophenolic acid | mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil | Homo sapiens | UDP + mycophenolic acid-acyl-glucuronide | - |
? | |
| UDP-glucuronate + mycophenolic acid | isozymes UGT1A9 and UGT2B7 | Homo sapiens | UDP + mycophenolic acid-acyl-glucuronide | - |
? | |
| UDP-glucuronate + mycophenolic acid | mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil | Homo sapiens | UDP + mycophenolic acid-phenyl-glucuronide | - |
? | |
| UDP-glucuronate + mycophenolic acid | isozymes UGT1A9 and UGT2B7 | Homo sapiens | UDP + mycophenolic acid-phenyl-glucuronide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
| UGT | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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