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Literature summary for 2.4.1.17 extracted from

  • Uchaipichat, V.; Mackenzie, P.I.; Guo, X.H.; Gardner-Stephen, D.; Galentin, A.; Houston, B.; Miners, J.O.
    Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of a 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid (2004), Drug Metab. Dispos., 32, 413-423.
    View publication on PubMed
Search for more literature for 2.4.1.17

Inhibitors

Inhibitors Comment Organism Structure
1-naphthol substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition Homo sapiens
4-Methylumbelliferone substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition; substrate inhibition Homo sapiens
acetone 30% and 40% inhibition of isozyme UGT2B15 at 1%, respectively; 30% and 40% inhibition of isozyme UGT2B17 at 1%, respectively Homo sapiens
acetonitrile 50% inhibition of isozyme UGT2B15 at 1% Homo sapiens
diclofenac
-
 Homo sapiens
DMSO 50% inhibition of isozyme UGT2B17 at 0.5% Homo sapiens
ethanol 50% inhibition of isozyme UGT2B17 at 1% Homo sapiens
additional information acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview; acetone, acetonitrile, dimethyl sulfoxide, ethanol, and methanol have only little inhibitory effect on the isozyme, overview Homo sapiens
probenecid
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information hyperbolic and sigmoidal kinetics for 4-methylumbelliferone and 1-naphthol for different isozymes, empirical and two-site models, overview Homo sapiens
0.008
-
 4-Methylumbelliferone isozyme UGT1A9, pH 7.4, 37°C Homo sapiens
0.009
-
 4-Methylumbelliferone isozyme UGT1A6, Michaelis-Menten kinetic, pH 7.4, 37°C Homo sapiens
0.014
-
 4-Methylumbelliferone isozyme UGT1A7, Michaelis-Menten kinetic, pH 7.4, 37°C Homo sapiens
0.031
-
 4-Methylumbelliferone isozyme UGT1A10, Michaelis-Menten kinetic, pH 7.4, 37°C Homo sapiens
0.113
-
 4-Methylumbelliferone isozyme UGT1A1, Michaelis-Menten kinetic, pH 7.4, 37°C Homo sapiens
0.253
-
 4-Methylumbelliferone isozyme UGT2B15, pH 7.4, 37°C Homo sapiens
0.335
-
 4-Methylumbelliferone isozyme UGT2B7, Hill equation, pH 7.4, 37°C Homo sapiens
0.73
-
 4-Methylumbelliferone isozyme UGT1A8, pH 7.4, 37°C Homo sapiens
1.159
-
 4-Methylumbelliferone isozyme UGT1A3, pH 7.4, 37°C Homo sapiens
4.204
-
 4-Methylumbelliferone isozyme UGT2B17, pH 7.4, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme UGT1A6
-
Homo sapiens
-
 isozyme UGT2B17
-
Homo sapiens O60656 isozyme UGT1A9; isozyme UGT1A9
-
Homo sapiens P16662 isozyme UGT2B7; isozyme UGT2B7
-
Homo sapiens P22309 isozyme UGT1A1; isozyme UGT1A1
-
Homo sapiens P22310 isozyme UGT1A4; isozyme UGT1A4
-
Homo sapiens P35503 isozyme UGT1A3; isozyme UGT1A3
-
Homo sapiens P54855 isozyme UGT2B15; isozyme UGT2B15
-
Homo sapiens Q9HAW7 isozyme UGT1A7; isozyme UGT1A7
-
Homo sapiens Q9HAW8 isozyme UGT1A10; isozyme UGT1A10
-
Homo sapiens Q9HAW9 isozyme UGT1A8; isozyme UGT1A8
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucuronate + 1-naphthol isozyme UGT1A1 Homo sapiens UDP + 1-naphthol beta-D-glucuronide
-
 ?
UDP-glucuronate + 1-naphthol isozyme UGT1A10 Homo sapiens UDP + 1-naphthol beta-D-glucuronide
-
 ?
UDP-glucuronate + 1-naphthol isozyme UGT1A3 Homo sapiens UDP + 1-naphthol beta-D-glucuronide
-
 ?
UDP-glucuronate + 1-naphthol isozyme UGT1A6 Homo sapiens UDP + 1-naphthol beta-D-glucuronide
-
 ?
UDP-glucuronate + 1-naphthol isozyme UGT1A7 Homo sapiens UDP + 1-naphthol beta-D-glucuronide
-
 ?
UDP-glucuronate + 1-naphthol isozyme UGT1A8 Homo sapiens UDP + 1-naphthol beta-D-glucuronide
-
 ?
UDP-glucuronate + 1-naphthol isozyme UGT1A9 Homo sapiens UDP + 1-naphthol beta-D-glucuronide
-
 ?
UDP-glucuronate + 1-naphthol isozyme UGT2B7 Homo sapiens UDP + 1-naphthol beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT1A1 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT1A10 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT1A3 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT1A6 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT1A7 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT1A8 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT1A9 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT2B15 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT2B17 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
UDP-glucuronate + 4-methylumbelliferone isozyme UGT2B7 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Homo sapiens
UGT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.23
-
 4-Methylumbelliferone isozyme UGT1A9, substrate inhibition, pH 7.4, 37°C Homo sapiens
0.33
-
 4-Methylumbelliferone isozyme UGT2B17, substrate inhibition, pH 7.4, 37°C Homo sapiens
1.16
-
 4-Methylumbelliferone isozyme UGT1A3, substrate inhibition, pH 7.4, 37°C Homo sapiens
1.26
-
 4-Methylumbelliferone isozyme UGT1A8, substrate inhibition, pH 7.4, 37°C Homo sapiens
1.74
-
 4-Methylumbelliferone isozyme UGT2B15, substrate inhibition, pH 7.4, 37°C Homo sapiens