Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phospholipids | - |
Homo sapiens | |
Triton X-100 | stimulates UGT1A9 activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
8 different UGT's expressed in baculovirus-infected cells as His-tagged proteins | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Triton X-100 | inhibition of UGT2B and almost all of the UGT1A isozymes, not inhibit glucuronidation of 1-naphthol nor scopoletin by UGT1A9, inhibition of entacapone glucuronidation tested on isozymes of UGT1A and UGT1B families, only for UGT1A9 showed reversible inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.061 | - |
scopoletin | apparent Km for membrane-bound UGT1AB | Homo sapiens | |
0.229 | - |
UDP-glucuronic acid | apparent Km for membrane-bound UGT1AB | Homo sapiens | |
0.704 | - |
UDP-glucuronic acid | apparent Km for purified UGT1AB | Homo sapiens | |
0.79 | - |
scopoletin | apparent Km for purified UGT1AB | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
microsome | - |
Homo sapiens | - |
- |
nuclear membrane | - |
Homo sapiens | 31965 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
His-tagged UGT1A9 purified by immobilized metal-chelating chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-naphthol + UDP-glucuronate | - |
Homo sapiens | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
scopoletin + UDPglucuronate | - |
Homo sapiens | UDP + scopoletin O-glucuronide | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | suggested homodimer | Homo sapiens |
? | all values determined by SDS-PAGE | Homo sapiens |