Cloned (Comment) | Organism |
---|---|
UGT1A3 expressed in COS-7 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
overview | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
12-hydroxybenzo[a]pyrene + UDP-glucuronate | glucuronidated by UGT1A3, inactive towards benz[a]pyrene trans 4,5 and 7,8 dihydrodiols | Homo sapiens | UDP + benzo[a]pyren-12-yl-beta-D-glucuronide | - |
? | |
2-hydroxyestrone + UDPglucuronate | glucuronidated by UGT1A3 and HGT1A9 | Homo sapiens | 2-hydroxyestrone 2-O-glucuronide + UDP | - |
? | |
5-hydroxybenzo[a]pyrene + UDPglucuronate | glucuronidated by UGT1A3 | Homo sapiens | UDP + 5-hydroxybenzo[a]pyrene O-glucuronide | - |
? | |
estriol + UDPglucuronate | UGT1A3 inactive | Homo sapiens | UDP + estriol-16 alpha-glucuronide | - |
? | |
estrone + UDPglucuronate | glucuronidated by UGT1A3 and HGT1A9 | Homo sapiens | UDP + estrone 3-O-glucuronide | - |
? | |
additional information | 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids | Homo sapiens | ? | - |
? | |
additional information | UGT1A3 inactive towards 4-hydroxyestrone and 16 alpha-hydroxyestrone | Homo sapiens | ? | - |
? | |
N-hydroxy-2-acetylaminofluorene + UDPglucuronate | glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives | Homo sapiens | UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide | - |
? |