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Literature summary for 2.4.1.16 extracted from

  • Zhuo, W.; Fang, Y.; Kong, L.; Li, X.; Sima, Y.; Xu, S.
    Chitin synthase A: a novel epidermal development regulation gene in the larvae of Bombyx mori (2014), Mol. Biol. Rep., 41, 4177-4186.
    View publication on PubMed
Search for more literature for 2.4.1.16

Cloned(Commentary)

Cloned (Comment) Organism
gene BmChsA, semiquantitative RT-PCR expression analysis, expression pattern Bombyx mori

Inhibitors

Inhibitors Comment Organism Structure
nikkomycin Z a chitin synthase inhibitor that downregulates the expression of BmChsA and decreases the amount of epidermis chitin during the molting process Bombyx mori

Organism

Organism UniProt Comment Textmining
Bombyx mori H6WW31 gene BmChsA
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Source Tissue

Source Tissue Comment Organism Textmining
epidermis gene BmChsA is an epidermis-specific expressed gene during the molting stage, BmChsA gene in the epidermis of the head Bombyx mori
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head BmChsA gene in the epidermis of the head Bombyx mori
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integument BmChsA is an integument-specific expressed gene Bombyx mori
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larva gene BmChsA is an epidermis-specific expressed gene during the molting stage Bombyx mori
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additional information semiquantitative RT-PCR expression analysis and expression pattern, overview Bombyx mori
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Synonyms

Synonyms Comment Organism
chitin synthase A
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 Bombyx mori

Expression

Organism Comment Expression
Bombyx mori nikkomycin Z, a chitin synthase inhibitor, downregulates the expression of BmChsA and decreases the amount of epidermis chitin during the molting process down
Bombyx mori exogenous hormones, 20-hydroxyecdysone and methoprene, significantly upregulate the expression of gene BmChsA at low levels of endogenous molting hormone and high levels of endogenous juvenile hormone immediately after molting. With low levels of endogenous hormones during the mulberry intake process, BmChsA is rarely upregulated by exogenous hormones. With high levels of endogenous molting hormone and low levels of endogenous juvenile hormone during the molting stage, upregulation of gene BmChsA by exogenous hormones is not detected up

General Information

General Information Comment Organism
malfunction knockdown of BmChsA gene in third instar larvae increases the number of non-molting and abnormal molting larvae Bombyx mori
physiological function chitin synthase is the key regulatory enzyme for chitin synthesis and excretion in insects, as well as a specific target of insecticides. Chitin synthase A gene BmChsA is an epidermis-specific expressed gene during the molting stage. Expression of gene BmChsA is regulated by endocrine hormones, which directly affect the chitin synthesis-dependent epidermal regeneration and molting process. BmChsA gene expression is strongly regulated by 20-hydroxyecdysone Bombyx mori