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Literature summary for 2.4.1.16 extracted from

  • Ji, Q.; Yang, D.; Wang, X.; Chen, C.; Deng, Q.; Ge, Z.; Yuan, L.; Yang, X.; Liao, F.
    Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents (2014), Bioorg. Med. Chem., 22, 3405-3413.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N,N-dipropylacetamide
-
Saccharomyces cerevisiae
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(2-nitrophenyl)acetamide
-
Saccharomyces cerevisiae
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(3-nitrophenyl)acetamide
-
Saccharomyces cerevisiae
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(4-(trifluoromethyl)phenyl)acetamide
-
Saccharomyces cerevisiae
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(4-methoxyphenyl)acetamide
-
Saccharomyces cerevisiae
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(4-nitrophenyl)acetamide
-
Saccharomyces cerevisiae
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(ptolyl)acetamide
-
Saccharomyces cerevisiae
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-methyl-N-phenylacetamide
-
Saccharomyces cerevisiae
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-phenylacetamide
-
Saccharomyces cerevisiae
3-(2-hydroxy-3-(methyl(2-oxo-2-(piperidin-1-yl)ethyl)amino)propyl)-1-methylquinazoline-2,4(1H,3H)-dione
-
Saccharomyces cerevisiae
fluconazole
-
Saccharomyces cerevisiae
methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate
-
Saccharomyces cerevisiae
additional information design, synthesis and evaluation of 1-methyl-3-substituted quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents, NMR and mass spectrometry structure analysis, overview Saccharomyces cerevisiae
N,N-dibenzyl-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl) (methyl) amino)acetamide
-
Saccharomyces cerevisiae
N,N-diethyl-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl) (methyl) amino)acetamide
-
Saccharomyces cerevisiae
N- benzyl-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl) amino)acetamide
-
Saccharomyces cerevisiae
N-(2-chlorophenyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamide
-
Saccharomyces cerevisiae
N-(4-(cyanomethyl)phenyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamide
-
Saccharomyces cerevisiae
N-(4-chlorobenzyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamide
-
Saccharomyces cerevisiae
N-(4-chlorophenyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamide
-
Saccharomyces cerevisiae
N-(tert-butyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl) amino)acetamide
-
Saccharomyces cerevisiae
Polyoxin B
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n Saccharomyces cerevisiae
-
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
?
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n Saccharomyces cerevisiae CGMCC 2.145
-
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae CGMCC 2.145
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
Saccharomyces cerevisiae UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
?
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
Saccharomyces cerevisiae CGMCC 2.145 UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
?

Synonyms

Synonyms Comment Organism
CHS
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.18
-
pH 7.0, 37°C Saccharomyces cerevisiae Polyoxin B