Literature summary for 2.4.1.16 extracted from

Kral, K.; Bieg, T.; Nawrot, U.; W?odarczyk, K.; Lalik, A.; Hahn, P.; Wandzik, I.
New monomeric and dimeric uridinyl derivatives as inhibitors of chitin synthase (2015), Bioorg. Chem., 61, 13-20.

Search for more literature for 2.4.1.16

Inhibitors

Inhibitors	Comment	Organism	Structure
5'-(N-succinyl)-5'-amino-5'-deoxyuridine	-	Saccharomyces cerevisiae
5'-(N-succinyl)-5'-amino-5'-deoxyuridine methyl ester	inhibits the yeast enzyme, and exhibits synergistic interaction with caspofungin against Candida albicans	Saccharomyces cerevisiae
5'-(N-succinylglycyl)-5'-amino-5'-deoxyuridine	-	Saccharomyces cerevisiae
5'-(N-succinylglycyl)-5'-amino-5'-deoxyuridine methyl ester	-	Saccharomyces cerevisiae
5'-deoxy-5'-(glycylamino)uridine	-	Saccharomyces cerevisiae
bis(5'-amino-5'-deoxyuridine) 2,2'-[(1,4-dioxobutane-1,4-diyl)diazanediyl]diacetate	50% inhibition at 3 mM	Saccharomyces cerevisiae
bis(5'-amino-5'-deoxyuridine) 4-[(carboxymethyl)amino]-4-oxobutanoate	-	Saccharomyces cerevisiae
bis(5'-amino-5'-deoxyuridine) succinate	-	Saccharomyces cerevisiae

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n	-	Saccharomyces cerevisiae	UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Saccharomyces cerevisiae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.8	-	pH 7.5, 25°C	Saccharomyces cerevisiae	5'-(N-succinyl)-5'-amino-5'-deoxyuridine methyl ester

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)