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Literature summary for 2.4.1.16 extracted from

  • Arakane, Y.; Specht, C.A.; Kramer, K.J.; Muthukrishnan, S.; Beeman, R.W.
    Chitin synthases are required for survival, fecundity and egg hatch in the red flour beetle, Tribolium castaneum (2008), Insect Biochem. Mol. Biol., 38, 959-962.
    View publication on PubMed
Search for more literature for 2.4.1.16

Protein Variants

Protein Variants Comment Organism
additional information adults treated with dsRNA for TcCHS-B exhibit little or no chitin in their PM and die about 2 weeks after injection, none of the TcCHS-B-treated females oviposite, which is probably a secondary effect caused by starvation, overview Tribolium castaneum
additional information when dsRNA for gene TcCHS-A is injected into male or female pharate adults, all insects die 5-7 d after the adult molt, and the females fail to oviposit prior to death, when dsTcCHS-A is injected into young adults 1-2 d post-eclosion, a similar lethal phenotype is obtained after 5 d and no oviposition occurs, when dsTcCHS-A injections are delayed until after adult maturation 7-10 d post-eclosion, the treated females do oviposit and the resulting embryos appear to develop normally, however, the chitin content of the eggs is dramatically reduced, the embryos became twisted and enlarged, and the eggs do not hatch, overview Tribolium castaneum

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Tribolium castaneum 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Tribolium castaneum chitin, synthesized by chitin synthase, is essential for the structural integrity of the exoskeletal cuticle and midgut peritrophic membrane of insects ?
-
 ?

Organism

Organism UniProt Comment Textmining
Tribolium castaneum Q6WD22 class-B CHS; red flour beetle, gene TcCHS-B
-
Tribolium castaneum Q6WD23 class-A CHS; red flour beetle, gene TcCHS-A
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information gene TcCHS-A expression during embryonic and adult development, overview Tribolium castaneum
-
additional information gene TcCHS-B expression during embryonic and adult development, overview Tribolium castaneum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information chitin, synthesized by chitin synthase, is essential for the structural integrity of the exoskeletal cuticle and midgut peritrophic membrane of insects Tribolium castaneum ?
-
 ?
additional information CHS catalyzes the synthesis of chitin, the beta-1,4-linked polymer of N-acetylglucosamine Tribolium castaneum ?
-
 ?

Synonyms

Synonyms Comment Organism
CHS
-
 Tribolium castaneum
class-A CHS
-
 Tribolium castaneum
class-B CHS
-
 Tribolium castaneum