Cloned (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
- |
Aspergillus nidulans |
- |
Candida albicans |
- |
Ustilago maydis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ni2+ | inhibition of chitin synthase 1 and 2, no inhibition of chitin synthase 3 | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chitosome | - |
Saccharomyces cerevisiae | 45009 | - |
plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | divalent cation required, chitin synthase 2 shows highest activity with chitin synthase 2 | Saccharomyces cerevisiae | |
Mg2+ | - |
Aspergillus nidulans | |
Mg2+ | divalent cation required, chitin synthase 1 and 3 have a preference for Mg2+ | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | Saccharomyces cerevisiae | - |
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | Aspergillus nidulans | chitin synthase 1 is involved in repair functions at the end of cytokinesis, chitin synthase 2 is responsible for the synthesis of the primary septum that separates mother and daughter cells, chitin synthase 3 is responsible for the formation of the ring where most of the cell wall chitin is located | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus nidulans | - |
- |
- |
Candida albicans | - |
- |
- |
Rhizopus microsporus var. oligosporus | - |
- |
- |
Saccharomyces cerevisiae | - |
chitin synthase 1, 2 and 3 | - |
Ustilago maydis | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | - |
Aspergillus nidulans |
proteolytic modification | - |
Candida albicans |
proteolytic modification | several proteases, including trypsin and chymotrypsin activate chitin synthase 1 and 2. Chitin synthase 3 requires the presence of substrate during protease treatment in order to be activated to some extent | Saccharomyces cerevisiae |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | level of chitin synthase 1 remains constant during vegetative growth in synchronised cells | Saccharomyces cerevisiae | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Saccharomyces cerevisiae | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Aspergillus nidulans | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Candida albicans | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Ustilago maydis | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Rhizopus microsporus var. oligosporus | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | chitin synthase 1 is involved in repair functions at the end of cytokinesis, chitin synthase 2 is responsible for the synthesis of the primary septum that separates mother and daughter cells, chitin synthase 3 is responsible for the formation of the ring where most of the cell wall chitin is located | Aspergillus nidulans | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? |