Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.155 extracted from

  • Huang, C.; Huang, M.; Chen, W.; Zhu, W.; Meng, H.; Guo, L.; Wei, T.; Zhang, J.
    N-acetylglucosaminyltransferase V modulates radiosensitivity and migration of small cell lung cancer through epithelial-mesenchymal transition (2015), FEBS J., 282, 4295-4306.
    View publication on PubMed
Search for more literature for 2.4.1.155

Application

Application Comment Organism
additional information an elevation of enzyme Gnt-V activity leads to radiosensitivity and migration of small cell lung cancer cells by inducing epithelial-mesenchymal transition, EMT, thereby highlighting Gnt-V as a potential therapeutic target for the prevention of EMT-associated tumour radioresistance and migration Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information silencing of the enzyme by expression of short hairpin RNAs specific to Gnt-V in small cell lung cancer cell lines H1688 and H146 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene ets-1
-

Source Tissue

Source Tissue Comment Organism Textmining
H-146 cell
-
 Homo sapiens
-
H-1688 cell
-
 Homo sapiens
-
small cell lung cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
GnT-V
-
 Homo sapiens
N-acetylglucosaminyltransferase V
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of enzyme Gnt-V increases the radiosensitivity of cancer cells. Increased enzyme activity leads to the radiosensitivity and migration of small cell lung cancer cells by inducing epithelial-mesenchymal transition. Overexpression of Gnt-V leads to a further increase in the relative viable cell number and survival fraction with a decrease in apoptosis rate and Bax/Bcl-2 ratio, when the cells are treated with irradiation. Downregulation of Gnt-V increased E-cadherin but suppressed ZEB2, vimentin and N-cadherin expression, while upregulation of enzyme levels leads to the downregulation of E-cadherin and upregulation of ZEB2, vimentin and N-cadherin at both the protein and mRNA levels Homo sapiens
additional information beta1,6-N-acetylglucosaminyltransferase V (GnT-V) is encoded by ets-1, a transcriptional factor which also regulates several enzymes associated with cell invasion and metastasis Homo sapiens
physiological function expression of enzyme Gnt-V correlates with the N stage in patients with small cell lung cancer. Increased enzyme activity leads to the radiosensitivity and migration of small cell lung cancer cells by inducing epithelial-mesenchymal transition. Gnt-V regulates the expression of epithelial and mesenchymal markers in SCLC cells Homo sapiens