Literature summary for 2.4.1.155 extracted from

Wang, X.; He, H.; Zhang, H.; Chen, W.; Ji, Y.; Tang, Z.; Fang, Y.; Wang, C.; Liu, F.; Shen, Z.; Qin, J.; Zhu, Y.; Liu, H.; Xu, J.; Gu, J.; Qin, X.; Sun, Y.
Clinical and prognostic implications of beta1,6-N-acetylglucosaminyltransferase V in patients with gastric cancer (2013), Cancer Sci., 104, 185-193.

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Application

Application	Comment	Organism
diagnostics	the enzyme is useful as diagnostic marker for gastric adenocarcinomas: low intratumoral MGAT5 density is associated with poor differentiation, N classification, TNM stage, and Kiel stage, and is an independent prognosticator for poor overall survival. The combination of intratumoral MGAT5 expression and TNM or Kiel staging systems has a better predictive power for overall survival. Applying the prognostic value of intratumoral MGAT5 density to TNM stage III+IV and Kiel stage IIIB+IV groups shows a better risk stratification for overall survival in patients with late-stage gastric cancer, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Homo sapiens	5794	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q09328	Chinese gastric adenocarcinoma patients, gene MGAT5	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
gastric adenocarcinoma cell	immunohistochemic analysis of 313 clinical samples, overview	Homo sapiens	-
stomach	non-tumor tissue shows strong expression of MGAT5, immunohistochemic analysis	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
beta1, 6-N-acetylglucosaminyltransferase V	-	Homo sapiens
Mgat5	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme expression is involved in the development of various cancers and their progression, through altering N-glycan branching, associations between MGAT5 expression and clinicopathologic features, overview. Kaplan-Meier survival analysis indicates that the overall survival of gastric cancer patients with low intratumoral MGAT5 expression is significantly poorer than those patients with high MGAT5 intratumoral expression	Homo sapiens

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Release 2023.1 (January 2023)