Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.155 extracted from

  • Alvarez-Manilla, G.; Troupe, K.; Fleming, M.; Martinez-Uribe, E.; Pierce, M.
    Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX) (2010), Glycobiology, 20, 166-174.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
NaCl up to 0.2 M, increase in enzyme activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transfection in HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ba2+ 30% of maximal activity Homo sapiens
Ca2+ 20% of maximal activity; 35% of maximal activity Homo sapiens
Cu2+ 30% of maximal activity Homo sapiens
EDTA 10% of maximal activity in absence of any cation and in presence in EDTA Homo sapiens
Fe2+ 15% of maximal activity Homo sapiens
Mg2+ 50% of maximal activity Homo sapiens
additional information 20% of maximal activity in absence of any 2+ cation Homo sapiens
NaCl more than 0.2 M, decrease in enzyme acitivty; more than 50 mM, decrease in enzyme acitivty Homo sapiens
Ni2+ 15% of maximal activity Homo sapiens
Zn2+ 10% of maximal activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
Ac-Val-Glu-Pro-(GlcNAcbeta(1-2)Manalpha1-O-)Thr-Ala-Val-NH2
-
Homo sapiens
0.53
-
GlcNAcbeta(1-2)Manalpha(1-2)Glc-O-octyl
-
Homo sapiens
0.56
-
UDP-N-acetyl-D-glucosamine
-
Homo sapiens
0.61
-
GlcNAcbeta(1-2)Manalpha1-O-benzyl
-
Homo sapiens
0.88
-
GlcNAcbeta(1-2)Manalpha1-O-benzyl
-
Homo sapiens
1.11
-
Ac-Val-Glu-Pro-(GlcNAcbeta(1-2)Manalpha1-O-)Thr-Ala-Val-NH2
-
Homo sapiens
1.62
-
UDP-N-acetyl-D-glucosamine
-
Homo sapiens
1.82
-
GlcNAcbeta(1-2)Manalpha(1-2)Glc-O-octyl
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 10mM, 4-fold stimulated enzyme activity Homo sapiens
Mn2+ decrease in enzyme activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + Ac-Val-Glu-Pro-(GlcNAcbeta(1-2)Manalpha1-O-)Thr-Ala-Val-NH2
-
Homo sapiens UDP + Ac-Val-Glu-Pro-(GlcNAcbeta(1-2)[GlcNAcbeta(1-6)]Manalpha1-O-)Thr-Ala-Val-NH2
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-2)Manalpha(1-2)Glc-O-octyl
-
Homo sapiens UDP + GlcNAcbeta(1-2)[GlcNAcbeta(1-6)]Manalpha(1-2)Glc-O-octyl
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-2)Manalpha(1-3)[GlcNAcbeta(1-2)Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc
-
Homo sapiens UDP + GlcNAcbeta(1-2)[GlcNAcbeta(1-6)]Manalpha(1-3)[GlcNACbeta(1-2)Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc
-
?
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-2)Manalpha1-O-benzyl
-
Homo sapiens UDP + GlcNAcbeta(1-2)[GlcNAcbeta(1-6)]Manalpha1-O-benzyl
-
?
UDP-N-acetyl-D-glucosamine + [GlcNAcbeta(1-2)][GlcNAcbeta(1-6)]Manalpha(1-3)[GlcNAcbeta(1-2)Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc
-
Homo sapiens UDP + [GlcNAcbeta(1-2)][GlcNAcbeta(1-6)]Manalpha(1-3)[[GlcNAcbeta(1-2)][GlcNAcbeta(1-6)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc
-
?

Synonyms

Synonyms Comment Organism
GnT-IX
-
Homo sapiens
GnT-V
-
Homo sapiens
GnT-VB
-
Homo sapiens
N-acetylglucosaminyltransferase V
-
Homo sapiens
N-acetylglucosaminyltransferase-Vb
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.5 7
-
Homo sapiens