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Literature summary for 2.4.1.153 extracted from
- Dolichyl phosphate-mannosyltransferase and dolichyl phosphate-N-acetylglucosaminyltransferase activities in liver preparations from normal controls and patients with cystic fibrosis and diabetes mellitus (1983), Clin. Chim. Acta, 134, 1-9.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Nonidet P-40 | detergent required | Homo sapiens |  |
| Triton X-100 | detergent required | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | divalent cation required, 5 mM Mn2+ is optimal | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + dolichyl phosphate | Homo sapiens | one of the initial steps of the lipid-mediated glycosylation pathway | UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
normal controls and patients with cystic fibrosis and diabetes mellitus | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | normal controls and patients with cystic fibrosis and diabetes mellitus | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
specific activities of dolichyl phosphate-mannosyltransferase are comparable in liver homogenates from normal controls and patients with cystic fibrosis and diabetes mellitus | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + dolichyl phosphate | - |
Homo sapiens | UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate | - |
? | |
| UDP-N-acetyl-D-glucosamine + dolichyl phosphate | one of the initial steps of the lipid-mediated glycosylation pathway | Homo sapiens | UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Homo sapiens |
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