Literature summary for 2.4.1.152 extracted from

Yang, X.; Zhang, Z.; Jia, S.; Liu, Y.; Wang, X.; Yan, Q.
Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation (2007), Int. J. Biochem. Cell Biol., 39, 1722-1730.

Search for more literature for 2.4.1.152

Application

Application	Comment	Organism
medicine	fucosyltransferase IV overexpression promotes cell proliferation, increases the expression of proliferating cell nuclear antigen and augments Lewis Y expression to trigger neoplastic cell proliferation, fucosyltransferase IV may serve as a potential therapeutic target for the treatment of Lewis Y-positive epithelial cancers	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in A-431 cells cells, two stable FUT-4 cell lines A431-FUT4-1 and A431-FUT4-2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P22083	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
uterus	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-fucose + Fucalpha1-2Galbeta1-4GlcNAcbeta1-R	-	Homo sapiens	GDP + Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-R	Lewis Y antigen, increased expression in cancer cells	?

Synonyms

Synonyms	Comment	Organism
fucosyltransferase IV	-	Homo sapiens

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Release 2023.1 (January 2023)