Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyldicarbonate | - |
Homo sapiens | |
NEM | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi trans-face | - |
Homo sapiens | - |
- |
secretory granule | granules of endothelial cells (Weibel-Parade bodies) | Homo sapiens | 30141 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | 20 mM Mn2+ are required for full activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | transcript of FUT6 mRNA detected | Homo sapiens | - |
blood plasma | in individuals with plasma fucosyltransferase deficiency from Indonesia, either a missense mutation, G739A, in the catalytic domain, or a nonsense mutation, C945A, truncating the COOH terminus of the enzyme, leads to the total loss of the enzymatic activity of FUT6. 9% of individuals on the island of Java lack the plasma type enzyme. Activity is elevated in patients with a variety of malignant disorders, including liver cancer, elevated in heavy alcohol drinkers. Reduction of enzyme level in patients with schizophrenia | Homo sapiens | - |
colon | transcript of FUT6 mRNA detected | Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
kidney | transcript of FUT6 mRNA detected | Homo sapiens | - |
liver | transcript of FUT6 mRNA detected | Homo sapiens | - |
milk | - |
Homo sapiens | - |
saliva | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
uterus | transcript of FUT6 mRNA detected | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Bos taurus | ? | - |
? | |
additional information | enzyme utilizes only type-2 chain polylactosamines as substrates, sialylated and nonsialylated oligosaccharides are good substrates, the enzyme produces sialyl Lewis X and Lewis X determinants | Homo sapiens | ? | - |
? | |
additional information | the enzyme is active on the polylactosamine substrate having 6-sulfate modification at the GlcNAc moiety and gives rise to sialyl and nonsialyl 6-sulfo Lewis X. The enzyme is also active on alpha(1,2) fucosylated type 2 chain substrates | Homo sapiens | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | 8 | - |
Homo sapiens |