Literature summary for 2.4.1.15 extracted from

Martinez-Esparza, M.; Martinez-Vicente, E.; Gonzalez-Parraga, P.; Ros, J.M.; Garcia-Penarrubia, P.; Argueelles, J.C.
Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans (2009), Int. J. Med. Microbiol., 299, 453-464.

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Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-

Expression

Organism	Comment	Expression
Candida albicans	a transitory increase in the expression of TPS2 and TPS1 genes is promoted in wild-type cells inresponse to acute, but not to gentleoxidative exposure	up

General Information

General Information	Comment	Organism
physiological function	disruption of the TPS2 gene encoding the only trehalose 6-phosphate phosphatase activity in Candida albicans causes a pleiotropic defective phenotype, maintaining the cell wall integrity and the ability to form chlamydospores. A homozygous tps2Delta/tps2Delta shows reduced growth at high temperatures and a marked sensitivity to heatshock and severe oxidative exposure. Exponential tps2Delta null cells display an adaptive response to oxidative stress as well as cross-tolerance between temperature and oxidative stress. Differential measurement of trehalose and trehalose 6-phosphate, revealed a significant accumulation of trehalose 6-phosphate in tps2Delta cells, which is enhanced after oxidative exposure. The level of trehalose 6-phosphate in parental cells is virtually undetectable, and oxidative treatment only induces the synthesis of free trehalose	Candida albicans

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Release 2023.1 (January 2023)