Activating Compound | Comment | Organism | Structure |
---|---|---|---|
heparin | - |
Mycobacterium tuberculosis |
Application | Comment | Organism |
---|---|---|
medicine | the enzyme should be a valuable target for chemotherapeutic intervention in tuberculosis | Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4 | - |
glucose-6-phosphate | with GDPglucose as glucosyl donor | Mycobacterium tuberculosis | |
7 | - |
glucose-6-phosphate | with UDPglucose as glucosyl donor | Mycobacterium tuberculosis | |
16 | - |
GDPglucose | - |
Mycobacterium tuberculosis | |
18 | - |
UDPglucose | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | 10 mM, 2fold increase of activity | Mycobacterium tuberculosis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
4 * 58000, SDS-PAGE | Mycobacterium tuberculosis |
220000 | - |
gel filtration | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDPglucose + glucose 6-phosphate | Mycobacterium tuberculosis | - |
trehalose 6-phosphate + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP-alpha-D-glucose + D-glucose 6-phosphate | - |
Mycobacterium tuberculosis | ADP + alpha,alpha-trehalose 6-phosphate | - |
? | |
CDP-glucose + D-glucose 6-phosphate | - |
Mycobacterium tuberculosis | trehalose 6-phosphate + CDP | - |
? | |
GDP-glucose + D-glucose 6-phosphate | - |
Mycobacterium tuberculosis | trehalose 6-phosphate + GDP | - |
? | |
TDP-glucose + glucose 6-phosphate | - |
Mycobacterium tuberculosis | trehalose 6-phosphate + TDP | - |
? | |
UDPglucose + glucose 6-phosphate | - |
Mycobacterium tuberculosis | trehalose 6-phosphate + UDP | - |
? | |
UDPglucose + glucose 6-phosphate | absolute specificity for glucose 6-phosphate | Mycobacterium tuberculosis | trehalose 6-phosphate + UDP | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 58000, SDS-PAGE | Mycobacterium tuberculosis |