Cloned (Comment) | Organism |
---|---|
gene B3gnt6 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | C3GnT-deficient mice on a C57BL/6 background | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q3USF0 | gene B3gnt6 | - |
Mus musculus C57BL/6 | Q3USF0 | gene B3gnt6 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
goblet cell | - |
Mus musculus | - |
intestine | - |
Mus musculus | - |
LS174T cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
C3GnT | - |
Mus musculus |
core 3 beta1,3-N-acetylglucosaminyltransferase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | stimulation of mucin-secreting LS174T cells with Nod1 and Nod2 agonists upregulates core 3 beta1,3-N-acetylglucosaminyltransferase and mucin 2 | up |
General Information | Comment | Organism |
---|---|---|
malfunction | disruption of the C3GnT gene reduces levels of colon-specific Muc2 protein. Nod agonists fail to enhance goblet cell numbers and Muc2 production in C3GnT deficient mice | Mus musculus |
physiological function | the enzyme is an important enzyme in mucin and core 3-derived O-glycans synthesis. Role of Nod proteins in regulation of intestinal goblet cell response in naive mice and mice infected with the enteric parasite Trichuris muris, overview. Nod proteins are important in postive enzyme regulation, treatment with Nod agonists upregulates C3GnT expression both in vivo and in vitro, overview | Mus musculus |