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Literature summary for 2.4.1.147 extracted from

  • Iwai, T.; Inaba, N.; Naundorf, A.; Zhang, Y.; Gotoh, M.; Iwasaki, H.; Kudo, T.; Togayachi, A.; Ishizuka, Y.; Nakanishi, H.; Narimatsu, H.
    Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans (2002), J. Biol. Chem., 277, 12802-12809.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Spodoptera frugiperda Sf21 cells via baculovirus infection as soluble FLAG-tagged fusion protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
additional information type II membrane protein Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
x * 43000, amino acid sequence determination Homo sapiens
46600
-
x * 46600, recombinant FLAG-tagged fusion protein, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R Homo sapiens R: polypeptide derived from mucin, involved in mucin oligosaccharide biosynthesis UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R Homo sapiens important role in synthesis of mucin-type O-glycans in digestive organs UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6ZMB0 enzyme form beta3-Gn-T6
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein recombinant FLAG-tagged fusion protein is glycosylated in insect cells Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant from Sf21 insect cells as FLAG-tagged fusion protein Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon normal colon, not colon cancer cells Homo sapiens
-
skeletal muscle low amount Homo sapiens
-
small intestine
-
Homo sapiens
-
stomach
-
Homo sapiens
-
testis low amount Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 4-nitrophenyl N-acetyl-alpha-D-galactosaminide recombinant protein, best substrate Homo sapiens UDP + 4-nitrophenyl N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminide
-
?
UDP-N-acetyl-D-glucosamine + asialofetuin recombinant protein Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-asialofetuin
-
?
UDP-N-acetyl-D-glucosamine + asialofetuin no activity with fetuin Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-asialofetuin
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-alpha-D-galactosaminyl-4-nitrophenyl recombinant protein, 2.4% activity compared to N-acetyl-beta-D-galactosaminyl-alpha-4-nitrophenyl Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-alpha-D-galactosaminyl-4-nitrophenyl
-
?
UDP-N-acetyl-D-glucosamine + bovine submaxillary gland mucin recombinant protein Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-mucin of bovine submaxillary gland
-
?
UDP-N-acetyl-D-glucosamine + bovine submaxillary gland mucin no activity with fetuin Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-mucin of bovine submaxillary gland
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-4-nitrophenyl recombinant protein, 15% activity compared to N-acetyl-beta-D-galactosaminyl-alpha-4-nitrophenyl Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-4-nitrophenyl
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R R: polypeptide derived from mucin, involved in mucin oligosaccharide biosynthesis Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R important role in synthesis of mucin-type O-glycans in digestive organs Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-MUC1 mucin
-
Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-MUC1 mucin N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosamine is bound to the glycoprotein via serine or threonine residues, resulting in a core 3 structure ?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-R activity is restricted to mucins from specific tissues, e.g. stomach, small intestine, and colon Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosamine is bound to the glycoprotein via serine or threonine residues ?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-R R: polypeptide derived from mucin Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosamine is bound to the glycoprotein via serine or threonine residues ?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-R no activity towards alpha-GalNAc residues of blood group A and the core 6 substrates, and beta-GalNAc residues of gangliosides, asialo-, lyso- and GalNAc-beta-1,4-(NeuAc-alpha-2,3-)Gal-beta-1,4-Glc-beta-1-1ceramide, i.e. GM2 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosamine is bound to the glycoprotein via serine or threonine residues ?

Subunits

Subunits Comment Organism
? x * 43000, amino acid sequence determination Homo sapiens
? x * 46600, recombinant FLAG-tagged fusion protein, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
beta3Gn-T6
-
Homo sapiens
core 3 synthase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Homo sapiens